Information
on QA Scheme: Pronuclear Assessment-2022
Comment = A scheme to QA the assessment status of day 1 human embryos using the modified criteria described by Scott(modified). The Z score used by Scott has been expanded to generate a normally distributed value for QA purposes.
Number of enrollments =56 [* This indicates only
the number of enrollments. Not all participants will have completed
the scheme]
List of QA Issues (or Instalments)
Code
Title
Available
from
HEB2022.01
Single pronuclear embryo.
1/1/2022
HEB2022.02
Single pronuclear embryo.
1/2/2022
HEB2022.03
Single pronuclear embryo.
1/3/2022
HEB2022.04
Single pronuclear embryo.
1/4/2022
HEB2022.05
Single pronuclear embryo.
1/5/2022
HEB2022.06
Single pronuclear embryo.
1/6/2022
HEB2022.07
Single pronuclear embryo.
1/7/2022
HEB2022.08
Single pronuclear embryo.
1/8/2022
HEB2022.09
Single pronuclear embryo.
1/9/2022
HEB2022.10
Single pronuclear embryo.
1/10/2022
HEB2022.11
Single pronuclear embryo.
1/11/2022
HEB2022.12
Single pronuclear embryo.
1/12/2022
List
of Questions asked for QA Scheme:Pronuclear Assessment-2022
Detailed
Information on Question: What is the pronuclear score for this zygote?
Status
This is the
KEY QAP Question for the Scheme
Type
Calculation Outcome
Order
Question
Options
1
The cummulative score is:
Title
Pronuclear Score-Complex
Comment
This score uses Scotts description plus other observations to create a numeric Z score for QA purposes
This
is a calculated Question. It requires a number of other questions
to be completed. The answer to these questions have each been weighted
(see below). The value submitted for each question is then compiled
as detailed below to provide a SCORE usually out of 100. The higher
the score usually indicates a better quality. The score is an arbitary
one and has been generated within QAPonline to allow all the parameters
embodies in the questions to be assess.
Order
Question
Calculation
Summation
1
Size of pronuclei
Value
*1
+
2
Juxtaposition of pronuclei
Value
*1
+
3
Nucleoli Synchrony
Value
*1
+
4
Nucleoli Number in PN#1 ( on left)
Value
*1
+
5
Nucleoli Number in PN#2 ( on right)
Value
*1
+
6
Nucleoli Number Comparison
Value
*1
+
7
Nucleoli Size
Value
*1
+
8
Nucleoli Location
Value
*1
+
9
Halo effect
Value
*1
+
10
Cytoplasmic Inclusions
Value
*1
+
1
Size of pronuclei
Order
Option
Value
Max
value
1
Equal and mature (large)
10
10
2
Unequal but mature (large)
5
10
3
Equal but Immature (small).
3
10
4
Unequal in size and maturity
1
10
2
Juxtaposition of pronuclei
Order
Option
Value
Max
value
1
Strongly together
10
10
2
Close or nearby
5
10
3
Not in contact - Disjuncted
2
10
4
Only one pronucleus present
0
10
3
Nucleoli Synchrony
Order
Option
Value
Max
value
1
Nucleoli synchronous - size, number and alignment similar
10
10
2
Nucleoli asynchronous - size, number and alignment dissimilar
5
10
4
Nucleoli Number in PN#1 ( on left)
Order
Option
Value
Max
value
1
<3 nucleoli
1
10
2
3-7 nucleoli
10
10
3
>7 nucleoli
1
10
5
Nucleoli Number in PN#2 ( on right)
Order
Option
Value
Max
value
1
<3 nucleoli
1
10
2
3-7 nucleoli
10
10
3
>7 nucleoli
1
10
6
Nucleoli Number Comparison
Order
Option
Value
Max
value
1
The number of nucleoli in each PN the same.
10
10
2
The number of nucleoli in each PN differ by one.
5
10
3
The number of nucleoli in each PN differ by more than one
KEY QAP Question for the Scheme