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DISCPLINES: Embryology Andrology Ultrasound Endocrinology
Modules HEB HEC HEE HEF HER HES HET HOva
 
Information on QA Scheme: Early Human Embryology QAP-2008
Comment = A series of images of human cleavage stage embryos for QC/QA purposes. The images may be either animated gif files, static multiple embryo images or 15 second videos in either avi,mpg or mov formats. The primary question used for quality assessments, the QAP question, is the same calculated embryo scrore parameter [ESP]. This allows for the assessment to be based upon the common criteria embryologists used in their daily embryo grading. The sum of each paramter leads to a calculated value that is submitted for assessment and comparison. The multiple images (4 per page) is used to assess comparative judgements for both transfer and for freezing. A text based summary has been included allowing participants to review how others describe and guage embryos. While the replies to all questions can be probed from conformity, the QAP question forms the basis for internal quality control and for external comparison for both each staff member and for the clinic overall.
Number of enrollments =359 [* This indicates only the number of enrollments. Not all participants will have completed the scheme]
List of QA Issues (or Instalments)
Code Title Available from
HEE2008.01-1 Single Human Embryo 1/1/2008
HEE2008.01-2 Three Day 2 Embryo 1/1/2008
HEE2008.02-1 Single Human Embryo 1/2/2008
HEE2008.02-2 Four day 2 embryos 1/2/2008
HEE2008.03-1 Single Day 3 Embryo 1/3/2008
HEE2008.03-2 Four Day 2 human embryos 1/3/2008
HEE2008.04-1 Single Day 3 Embryo 1/4/2008
HEE2008.04-2 Four Human Embryo at 68hr 1/4/2008
HEE2008.04-3 Day 3 Embryo 1/4/2008
HEE2008.05-1 Single Day 3 Embryo 1/5/2008
HEE2008.05-2 Day 3 Embryo A 1/5/2008
HEE2008.05-3 Day 3 Embryo B 1/5/2008
HEE2008.05-4 Grade Embryos 1/5/2008
HEE2008.06-1 Single Day 3 Embryo 1/6/2008
HEE2008.06-2 Four Day 2 Human Embryo 1/6/2008
HEE2008.07-1 Single Day 3 Embryo 1/7/2008
HEE2008.07-2 Four Day 3 Human Embryo 1/7/2008
HEE2008.08-1 Single Day 3 Embryo 1/8/2008
HEE2008.08-2 Four Day 3 Human Embryo 1/8/2008
HEE2008.09-1 Single Day 3 Embryo 1/9/2008
HEE2008.09-2 Four Day 3 Human Embryo 1/9/2008
HEE2008.10-1 Single Day 3 Embryo 1/10/2008
HEE2008.10-2 Four Day 3 Human Embryo 1/10/2008
HEE2008.11-1 Single Day 3 Embryo 1/11/2008
HEE2008.11-2 Four Day 3 Human Embryo 1/11/2008
HEE2008.12-1 Single Day 3 Embryo 1/12/2008
HEE2008.12-2 Three Human Embryo 1/12/2008
HEE2008.12-3 Single day 3 Embryo 1/12/2008
List of Questions asked for QA Scheme:Early Human Embryology QAP-2008
ID Question Question Format
9 Describe the degree of compaction. Defined Options
203 Explain why you selected one embryo over the others for transfer? Educational Outcome
216 Explain why you would choose to freeze or discard each embryo. Educational Outcome
223 How even are the size of the blastomeres. Defined Options
207 How many cells are in the embryo Numeric Outcome
202 How would you describe this embryo AND GRADE BY YOUR OWN CLINICS GRADING PROCESS? Educational Outcome
505 If this embryo was one of several to be frozen or discarded, what would you decide? Defined Options
3 If this was the only embryo availble for freezing, would you freeze it ? Defined Options
585 If your clinic cultured to day 5, would you submit embryo A to blastocyst culture? Defined Options
586 If your clinic cultured to day 5, would you submit embryo B to blastocyst culture? Defined Options
587 If your clinic cultured to day 5, would you submit embryo C to blastocyst culture? Defined Options
588 If your clinic cultured to day 5, would you submit embryo D to blastocyst culture? Defined Options
28 Is the rate of cleavage normal? Defined Options
211 What is the % fragmentation on this embryo Numeric Outcome
206 What is the embryo score for this embryo Calculation Outcome
27 Which embryo would you rank first? Defined Options
41 Which embryo would you rank fourth? Defined Options
39 Which embryo would you rank second. Defined Options
40 Which embryo would you rank third? Defined Options
212 Would you freeze embryo A? Defined Options
213 Would you freeze embryo B? Defined Options
214 Would you freeze embryo C? Defined Options
215 Would you freeze embryo D? Defined Options
1 Would you transfer this embryo if it was the best or only embryo available for transfer? Defined Options
This question has been used in the following computations. - See Calculated Q for more details
Embryo Score-Ver 1
Detailed Information on Question: What is the embryo score for this embryo
Status This is the KEY QAP Question for the Scheme    
Type Calculation Outcome
Order Question Options
1 The calculated embryo score is:
Title Embryo Score-Ver 1
Comment This score calculates the number of cells *[cleavage+ Fragmentation+cell size+compaction]
This is a calculated Question. It requires a number of other questions to be completed. The answer to these questions have each been weighted (see below). The value submitted for each question is then compiled as detailed below to provide a SCORE usually out of 100. The higher the score usually indicates a better quality. The score is an arbitary one and has been generated within QAPonline to allow all the parameters embodies in the questions to be assess.
Order Question
Calculation
Summation
1 How even are the size of the blastomeres.
Value *1
+
2 What is the % fragmentation on this embryo
Value (100-x)/100100
+
3 Is the rate of cleavage normal?
Value *1
+
4 Describe the degree of compaction.
Value *1
+
5 How many cells are in the embryo
Value *1
*
1 How even are the size of the blastomeres.
Order Option
Value
Max value
1 The blastomeres appear of equal size
1
1
2 The blastomeres differ only marginally in size
0.75
1
3 The blastomeres differ significantly in size
0.5
1
5 How many cells are in the embryo
Order Option
Value
Max value
1 The number of cells are
0
25
2 What is the % fragmentation on this embryo
Order Option
Value
Max value
1 The % fragmentation is:
0
1
3 Is the rate of cleavage normal?
Order Option
Value
Max value
1 YES, this embryo is normal.
1
1
2 No - this embryo has cleaved or developed faster than expected.
0.75
1
3 No, the embryo is delayed.
0.5
1
4 No, the embryo has arrested or significantly delayed.
0.25
1
5 No, the embryo is abnormal.
0.1
1
4 Describe the degree of compaction.
Order Option
Value
Max value
1 NO compaction is evident
1
1
2 Preliminary Cell Attachment is evident
1.5
1
3 Significant Cell attachment is evident
1.75
1
4 Compaction is Complete
2
1
 
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