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R2011.16
Vitamin D is positively associated with sperm motility and increases intracellular calcium in human READ ON
In this report, Jensen et.al. have shown 44% of men have insufficient Vitamin D levels in their blood and this may impact on sperm motility and morphology.
 
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Background.
   
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Vitamin D (Vit D) it its receptor (VDR) have been implicated in male reproduction since VDR is found on human spermatozoa and knockout mouse strains have an infertile phenotype. One mode of action is via calcium homeostasis. This study by Jensen et. al. looks at the role of Vit D on human semen profiles in 40 men whose partners are undertaking IVF and in 300 men from the general population.
 
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Observations
   
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They reported that 44% of men had Vit D insufficiency that has a seasonal aspect and the serum Vit D concentration was correlated to sperm motility and morphology but not concentration nor any endocrinology including Inhibin B and FSH. Addition of an activated from of VD to human sperm increased in internal calcium levels, motility and the acrosome reaction (a measure of capacitation).
 
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Conclusions
   
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The authors suggested that since VDR (receptor) is found on the midpiece of human spermatozoa, a role for it may exist in the female reproductive tract and this may be related to motility. The link to motility appears via the role of Vit D in the release of intracellular calcium. Evidence for a role in capacitation is unclear.
 
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Comments.
   
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Given recent reports of Vit D insufficiency in women as well, the role of Vit D in a seasonal aspect to human fertility is tantalizing. While the relationships between Vit D serum concentrations and motility and morphology in the ejaculate were modest, they do suggest that astheno-teratospermic males may benefit from Vit D assessment and supplementation if low. While this treatment has not been linked to Vit D, male supplements have been linked to limited improvements in semen profile. The Vit D relationship is one more part of a link between lifestyle and male reproductive health.
Martin Blomberg Jensen, et. al. (2011) Vitamin D is positively associated with sperm motility and increases intracellular calcium in human spermatozoa.Human Reproduction, Vol.26, No.6 pp. 1307 1317, 2011 - View
Reviewed on 22/05/2011 3:39:20 PM by J D Stanger
Review Groups: Semen Profile / Male Infertility /
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