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A randomized controlled study of human serum albumin and serum substitute supplement as protein supplements for IVF culture and the effect on live bir
SSS added to commercial HSA-supplemented embryo culture media resulted in an overall increase in implantation and live birth rates - Protein enrichment of media may significantly improve the blastocyst implantation rate, creating opportunities to transfer single blastocysts without compromising the live birth rate.
humrep.oxfordjournals.org/content/24/4/782.abstract
94. Protein format influences outcomes [Business Announcements]
from: Administrator (office@fertaid.com), Australia on 25/07/2014 8:38:51 AM Profession:
Comment: A randomized controlled study of human serum albumin and serum substitute supplement as protein supplements for IVF culture and the effect on live birth rates. HR (2009)
Submission: I came across this reference in HR after reading the chapter on Macromolecules in EMBRYO CULTURE by Smith et.al. This chapter and the above article highlight a continuing problem in IVF media in that there remains considerable variation in the macromolecules used in IVF. This will become more important when using time-lapse imagery to identify the best embryos.It would seem to me that the impacts of media formulations on cleavage rates need to be resolved before commercial time points are set. Having said this, most time points are for the early cleavage benchmarks where the influence of macromolecules may be of less importance.
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