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Association between ambient air pollution and pregnancy rate in women who underwent IVF
This study provided evidence of an association between increased ambient concentrations of PM10, NO2 and CO and reduced probabilities for achieving intrauterine pregnancy using multiple IVF cycle data. Specifically, our results indicated that lower intrauterine pregnancy rates in IVF cycles may be linked to ambient air pollution during COS and the post-transfer period.
academic.oup.com/humrep/advance-article-abstract/doi/10.1093/humrep/dey076/4962139
222. Can ambient air pollution influence the chance and outcome of pregnancy? [Commentary]
from: Administrator (office@fertaid.com), Australia on 23/05/2018 12:14:23 AM Profession:
Comment: The authors reported that exposure to PM,CO and NO2 (but not SO2 and O3) after embryo transfer decreased the chance of pregnancy and the outcome of pregnancy
Submission In this South Korean article, the authors looked at averaged air pollutant concentration PM (particulate matter), CO, NO2, SO2 and O3 from general published environmental data and related the level of pollution to pregnancy outcomes during the whole IVF treatment cycle. They reported that high exposure of both PM, CO and NO2 during the post embryo transfer period (implantation period) decreased both the chance of pregnancy and the miscarriage rate.
While they acknowledged that other factors such as smoking may be contributing effects, the power of the study lay in the 6621 cycles from 4581 patients between 2006 and 2014. It seems the data related only to IVF cycles and it would be interesting the results for a similar study from FET cycles. It was assumed most of the pollution arose from vehicle traffic.
This impressive paper demonstrated that the environment in which couples are trying to conceive may directly influence their chance of pregnancy and the likelihood the pregnancy will proceed to term. Perhaps clinics working in pristine climates (with little traffic) may like to use this information to promote their clinics but the paper does imply that the environment outside the laboratory has an influence on their success rates. There is a lot of information on the sources of VOC toxicity from laboratory processes on pregnancy and reports of pregnancy reductions during building renovations including car park resurfacing but this paper extends this concept to exposure after the embryos have been transferred. Should clinics explain this to couples where treatment is in a highly polluted city and maybe have a holiday after the transfer? If the clinic is in a highly polluted city, then monthly KPI data may vary during the seasons when the pollution levels may change.
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