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Effect of the sexual abstinence period recommended by the World Health Organization on clinical outcomes of fresh embryo transfer cycles with normal o
In conclusion, SAP (sexual abstinence period) beyond the recommended period by WHO was not associated with the rates of a lower fertilisation and pregnancy in human in vitro fertilisation (IVF). We think that a new criterion of SAP for clinical application in human IVF needs to be considered by WHO.
216. Does sexual abstinence effect IVF(ICSI) outcomes. [Forum/Discussion]
from: Administrator (office@fertaid.com), Australia on 12/03/2018 12:10:19 AM Profession:
Comment: The short answer is no.
Submission: A small retrospective study from a South Korean clinic that compared the clinical outcome of using spermatozoa via ICSI from semen samples of less than or more than 8 days. Both fresh and 'aged' samples produced the same pregnancy rate after swim-up preparation (an older method for recovering motile sperm).// Most would not be surprised by this observation however IVFDaily included this article in a mailout because it reflects the difference between the WHO standard for semen analysis that is largely based on coital fertility (natural pregnancy) rather than clinical fertility (at a clinic). When a couple attend for fertility treatment, in most cases, one or more semen analyses are performed and based upon this, a clinical recommendation is made as to whether IVF (& ICSI) may provide a better chance of pregnancy than currently experienced.// The issue arises as in this case as to whether a sample may be accepted for IVF (& ICSI) based upon the coital based normal ranges. As this article demonstrates that rejecting a sample because of atypically long abstinence is of little value since even in an 'aged' sample, normal fertile sperm can be recovered to achieve fertilisation and pregnancy. In some ways it questions the value of applying the WHO normal ranges when applied to predicting the fertility of a sample used in IVF/ICSI.// Having said this, there have been observations that if the sample demonstrated high levels of sperm DNA damage, repeated ejaculations can significantly improve the DNA integrity of the sample and since high DNA fragmentation may impact on miscarriage rates, a clinic who accepts an 'aged' sample from a client with high DNA fragmentation may not be a good idea, particularly if the client falls pregnant and miscarries!.//
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