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Effect of Growth Hormone on Uterine Receptivity in Women With Repeated Implantation Failure in an Oocyte Donation Program: A Randomized Controlled Tri
Conclusion: Our data of improved implantation, pregnancy, and live birth rates among infertile RIF patients treated with GH indicate that GH improves uterine receptivity.
212. Can growth hormone (GH) improve the likelihood of pregnancy in older women? [Forum/Discussion]
from: Administrator (office@fertaid.com), Australia on 9/03/2018 11:01:35 PM Profession:
Comment: For older women (>40) with previous unsuccessful treatment, GH may improve the endometrial capability and receptivity increasing the pregnancy and live birth rate.
Submission: Previous publications investigating the potential of GH to improve outcomes in older women who have previously be unable to achieve pregnancies, have found that GH may improve outcomes by improving oocyte (and hence embryo) viability. Improved outcomes in frozen embryo cycles clearly pointed to an oocyte process.// However, this paper by Spanish researchers in the Journal of the Endocrine Society argues quite effectively that GH may also act on the endometrium. Using donor oocytes and recipient women exposed to GH during the E2 phase of HRT stimulation, their results demonstrate that the GH exposed clients had a thicker endometrium and more implantations and live births that those without GH treatment (51% x 17%).// While this study needs to be repeated, the addition of GH to older women undergoing HRT prior to embryo transfer and well prove to be an easy inclusion in any FET treatment protocol for older women. It also provides a different insight into the problems of reduced fertility with increasing age from an alternative approach of uterine receptivity rather than purely oocyte viability. //
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