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Whither human IVF? Fertilisable oocytes selected on the basis of follicular temperature
Human pre-ovulatory follicles have previously been reported to be cooler than other ovarian tissues, so the divergence between ovulatory and non-ovulatory follicle temperature suggests a valuable addition to selection procedures currently used in human in vitro fertilisation (IVF) clinics. In future, oocytes to be subjected to IVF might best be those taken from cooler follicles. Follicular antral temperature could become a more sensitive indicato
209. Is Follicle temperature linked to oocyte quality? [Forum/Discussion]
from: Administrator (office@fertaid.com), Australia on 28/02/2018 12:12:06 PM Profession:
Comment: Recent followup work in cattle have confirmed graffian preovulatory follicles are cooler than surrounding tissue suggesting follicle temperature may be an alternative tool to oocyte selection.
Submission: The initial link between follicle temperature and follicle maturity was made in cattle during the early days of IVF but never really gained the IVF communities attention mainly for logistical and species reasons. This paper has revisited this issue (again in cattle) and confirmed that large, preovulatory follicles are 1.5C cooler than surrounding tissue. While direct relationship between oocyte quality and follicle temperature remains to be determined, IVFDaily considered that the concept of temperature monitoring of follicles prior to or during oocyte collection may provide an alternative and less invasive tool to identify those follicles more likely to provide a viable embryo for transfer.//Given that only about 8% of oocytes end up as a child, IVF spends considerable effort to try and sort the viable from the less viable embryos including time-lapse systems and PGS tools. While the sperm most likely contributes significant errors in embryo viability as does the culture systems, few clinics make any effort to sort oocytes on their quality part from polar body status at ICSI. All sorting is usually performed post insemination. Any easy tool that may dynamically identify healthy follicles at collection may in time provide a valuable tool. One reason why follicle blood flow never gained traction was the difficulty in identifying those follicles with well developed capillary systems. As the authors suggest, using a needle with a thermister attachment or an ultrasound tool may make follicle temperature a useful tool to sort the good eggs from the not-so-good ones. Maybe there is a market opportunity for an inventive needle maker!//
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