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Maternal age at birth and daughters’ subsequent childlessness
Compared with women born to 20–24-year-old mothers, those born to mothers aged 25–29, 30–34 and ≥:35 years were more likely to be childless [RR (95% CI): 1.21 (1.14–1.29), 1.30 (1.22–1.39) and 1.40 (1.31–1.50), respectively]. The association was consistent in strata defined by birth cohort, number of siblings, birth order, and participant’s educational level, as well as within sister pairs. Overall, we found weak evidence for an independent
academic.oup.com/humrep/advance-article-abstract/doi/10.1093/humrep/dex350/4685990?redirectedFrom=fulltext
205. Are children of Older Mothers more likely to remain childless? [Forum/Discussion]
from: Administrator (office@fertaid.com), Australia on 15/12/2017 11:49:30 AM Profession:
Comment: In a large epidemiological study, females born to older women are more likely to not to have children themselves.
Submission: At first glance reading this abstract I assumed the reason maybe due to older women would also have older partners and older males may be the reason for if you like secondary infertility. However, the data suggests this is not the primary reason. The authors cite other human and animal studies suggesting older mothers (or eggs from older women) have reduced fertility (biological or other reasons).// Even though this is an epidemiology study using a cancer patient database, the study limited itself to cancer free clients with siblings who had cancer and who were more than 44 years old. Self reporting of maternal age at their birth and the number of children was the basis of the dataset that had more than 43,000 clients.// The increased childlessness of women born to older mothers was apparent over most social parameters. There was a weak link to partners paternal age. The implication are clear from this association that women who were conceived later in their mothers reproductive age are less likely to have a live birth. While there are many social reasons for this, this is not an isolated observation - there being some references cited by the authors for similar observation elsewhere and one cannot rule out a biological basis as well. Whether the primary reason is social or biological (ova from older women had different fecundity to these of younger women) is unclear but clinics treating older women may well be wise to indicate this observation to their clients so at least they are aware of the findings. Maybe in the future, research on oocyte quality may throw further light on the viability of oocytes to produce fertile offspring. This is not an IVF specific thing since the study looked at women who presumably have conceived naturally but if IVF could improve oocyte selection them maybe it may be a good thing./
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