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Does poor ovarian response to gonadotrophins predict early menopause? A retrospective cohort study with minimum of 10-year follow-up
A total of 219 women (64 poor responders, 155 good responders) returned their questionnaires. Poor responders were more likely to have premature menopause (3% vs. 0%: p := :.024). A higher proportion of poor responders experienced early menopause (11% vs. 3%: p := :.044). Poor response to gonadotrophins in the context of IVF treatment is a marker of reduced ovarian reserve and is associated with early menopause.
195. Response to stimulation and menopause [Forum/Discussion]
from: DrJamesStangerPhD (office@fertaid.com), Australia on 25/08/2016 7:39:24 AM Profession:
Comment: A single clinic study over 10 years has suggested a poor response to stimulation may be a marker of early menopause
Submission: Probably not a surprising study since poor response to stimulation is linked to low AMH and diminished ovarian reserve. One interesting aspect of this study is that with knowledge that if a poor response anticipates an early menopause, does this influence a clinics management of the couple. Since all couples have a preconceived sense of how many children will satisfy their need for a family, would an early menopause encourage a clinic to offer more embryos at transfer even with an increased risk of multiple pregnancy or maybe suggest a quick return to treatment and leave any frozen embryos in storage hopefully to build up a stockpile.
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