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Anti-Müllerian hormone serum concentrations of women with germline BRCA1 or BRCA2 mutations
BRCA1 mutation carriers had, on average, 25% (95% CI: 5%–41%, P = 0.02) lower AMH concentrations than non-carriers and were more likely to have AMH concentrations in the lowest quartile for age (OR 1.84, 95% CI: 1.11–303, P = 0.02). There was no evidence of an association between AMH concentration and BRCA2 mutation status (P = 0.94).
humrep.oxfordjournals.org/content/early/2016/04/08/humrep.dew044.abstract
193. High ICSI Treatment numbers. [Forum/Discussion]
from: Administrator (office@fertaid.com), Australia on 22/08/2016 10:58:02 AM Profession:
Comment: The recent ICMART data (albeit from 2010) show ICSI rates are higher than expected for male infertility and variable between regions
Submission: Apart from financial reason to promote ICSI, there may be several reasons why the ICSI rates are higher than expected. The main ones include the fear of failed fertilisation, a desire to standardize the IVF treatment process and a growing body of data that suggests the risk from using ICSI remain low or negligible.//There are some other comments that can be made including a rising ICSI rate means less emphasis on Andrology workup and assessment of male fertility, less skill retention by embryologists to perform standard IVF and handling cumulus enclosed oocytes and fertilised eggs. Finally, the unfertilised oocyte is the most vulnerable of all stages of embryo culture and be definition means that culture systems need to be of the best quality.
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