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Age of G-1 PLUS v5 embryo culture medium is inversely associated with birthweight of the newborn
Age of G-1 PLUS v5 medium used to culture human embryos affects birthweight of the respective newborn. This could imply that the preimplantation embryo adapts to its in vitro environment with lasting in vivo consequences. Therefore, it is important that companies are transparent about the exact composition of their embryo culture media, which will allow IVF clinics to further investigate the effects of the media or media components on the health
185. Culture age influences birthweight. [Laboratory Enquiry]
from: Administrator (office@fertaid.com), Australia on 17/06/2015 10:47:56 AM Profession:
Comment: In this interesting study, Kleijkers, et.al looked at the age from production to use and found that the older the media, the lower the birthweight of infants born.
Submission The authors looked at the age of culture media not from date of opening but from date of production and found that the older the media was had no effect on fertilisation and cleavage rates, on embryo quality nor on ongoing pregnancy rate.
By using data over many years and adjusting for confounding factors, media age of more than 65 days was associated with a deceased birthweight of 234 gms. This may be a set of data media manufacturers would find difficult to access and monitor and as the article indicates, may not be representative of all media.
However, since most media is similar, there would be an expectation that their observations could be similar. The point is that while concerns of media effects on large babies have been often implied (from cattle work), this data suggests that aging of media may influence energy substrates rather than protein. The concern expressed by the authors is that this demonstrates in vitro effects can have in vivo consequences. However, the age of the media at use is a clinic liability. Many clinics order large bottles of media to avoid costs and are often used right up to the expiry date. Almost certainly, few if any clinics monitor the age of the media apart from the use by date and few would have foreseen this outcome.
Given relationships between birthweight and adult well-being and health, clinics may need to review their management of media and their supply chain to minimise excessive storage. If a couple asked what age of media was used for their attempt, few clinics could easily reply since it is not a common KPI or cycle statistic. This article suggest it would be worthwhile to do so in the future.
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