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Paternally contributed centrioles exhibit exceptional persistence in C. elegans embryos
The two gametes make different contributions to the zygote at fertilization. Although both gametes contribute genetic material, in most animal species the oocyte donates the bulk of cytoplasmic constituents and cellular organelles, including mitochondria, whereas the sperm donates two centrioles
www.nature.com/cr/journal/vaop/ncurrent/full/cr201549a.html
182. Beyond genes: Are centrioles carriers of biological information? [Forum/Discussion]
from: Administrator (office@fertaid.com), Australia on 25/04/2015 2:23:26 PM Profession:
Comment: EPFL scientists discover that certain cell structures, the centrioles, could act as information carriers throughout cell generations.
Submission: Quote `In summary, our data demonstrate that paternally contributed centriolar components exhibit remarkable persistence in the embryo. Given that b-tubulin, SAS-4 and SAS-6 are core structural components of centrioles, the entire centriole organelle could be considered to exhibit exceptional persistence across many cell cycles. It will be of interest to determine whether such exceptional persistence can be extended to centrioles of somatic cells in nematodes and also to other systems. Macromolecular complexes other than centrioles exhibit long-term persistence. This is the case for example of nucleopores in terminally differentiated cells, where cumulative damages in some nucleopore constituents have been linked to cell aging, both in C. elegans and rats10. Similarly, cumulative damages of centriolar components exhibiting long-term persistence could eventually be detrimental to function and even contribute to disease. Our findings also raise the intriguing possibility that centrioles may act as information carriers across several cell cycles, for instance through posttranslational modifications of the persistent centriolar proteins reported here. Conceivably, this could also allow the paternal gamete to donate dedicated information to the zygote, in a manner that is conceptually analogous and reciprocal to the contribution of maternally provided mitochondria.` end quote
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