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Freeze-all policy: fresh vs. frozen-thawed embryo transfer
Conclusion(s) The IVF outcomes were significantly better in the group using the freeze-all policy, compared with the group using fresh ET. These results suggest that even in a select group of patients that underwent fresh ET (P levels ≤:1.5 ng/mL), endometrial receptivity may have been impaired by COS, and outcomes may be improved by using the freeze-all policy.
178. Freeze-all policy: fresh vs. frozen-thawed embryo transfer [Forum/Discussion]
from: Administrator (office@fertaid.com), Australia on 11/03/2015 1:10:38 PM Profession:
Comment: FET continues to out perform ET and raises question whether clinics can find a way to only do FET?
Submission: IN this study FET pregnancy rates (implantation clinical and ongoing) were better by about 5% to fresh ET. Most clinics would agree with this observation and one wonders whether if a clinic provides couples with this information and offers them a choice of ET or FET, how many would take it. In the past, even back as far as 1988, clinics were trying to find ways to put the best embryos back as FET transfers. Unfortunately, no-one liked the idea of doing an ET with a poor quality embryo. However, where a women has OHSS and the transfer is delayed, no-one seems to mind (probably because they are not feeling well!!). One option is to have a fee structure that includes the IVF collection and an FET cycle. If presented to couples as an option that may give them a better chance of pregnancy and if they know there is only 1-2 good embryos anyway, they may agree. The killer point against this is if the embryos fail to survive freezing or develop into blastocysts. No-one has solved this paradox but it doesn't mean clinics should strive to find a way to deliver the best rate possible.
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