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Effect of sperm DNA fragmentation on the clinical outcomes for in vitro fertilization and intracytoplasmic sperm injection in women with different ova
Conclusion(s): Sperm DNA fragmentation (SDF) has a greater impact on IVF and ICSI outcomes among women with ROR(reduced ovarian reserve), so SDF testing may be of particular clinical significance for these couples.
www.fertstert.org/article/S0015-0282(15)00052-7/fulltext
177. Effect of sperm DNA fragmentation on IVF/CISI in women with different ovarian reserves [Forum/Discussion]
from: Administrator (office@fertaid.com), Australia on 11/03/2015 12:41:39 PM Profession:
Comment: Not surprisingly, the level of Sperm DNA damage has differing impacts on women with diminished ovarian reserve.
Submission: There are two things of interest in this paper. First is confirmation that even in women with normal ovarian reserve, elevated sperm DNA fragmentation (SDF) is related to increased rates of miscarriage. It seems that clinics who do NOT carry out an SDF test and treatment results in miscarriage may be exposing themselves to complaint. Unfortunately, in this study, IVF and ICSI produced the same outcomes. The authors identified a SDF level of 27% as the critical cutoff point. However the main feature of the article was that the SDF level significantly influenced the rate that live birth rates were diminished in women with decreased ovarian reserve. That is, when addressing the problem of age related success rates, the degree of male related sperm damage needs to be also considered. The authors suggested this may be interpreted as an indication that poor oocyte quality may be unable to correct the sperm DNA damage. While the concept of oocyte restoration of sperm quality as been around for some time, little data actually exists to demonstrate this. This interesting article may just provide a small glimpse that oocytes can actually correct some sperm DNA fragmentation issues.
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