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Cumulative alkylating agent exposure and semen parameters in adult survivors of childhood cancer: a report from the St Jude Lifetime Cohort Study
Interpretation: Impaired spermatogenesis was unlikely when the CED was less than 4000 mg/m2. Although sperm concentration decreases with increasing CED, there was substantial overlap of CED associated with normospermia, oligospermia, and azoospermia. These data can inform pretreatment patient counselling and use of fertility preservation services.
www.thelancet.com/journals/lanonc/article/PIIS1470-2045(14)70408-5/fulltext
101. Cumulative alkylating agent exposure and semen parameters in adult survivors of childhood cance [Forum/Discussion]
from: Administrator (office@fertaid.com), Australia on 19/09/2014 9:26:01 AM Profession:
Comment: An important publication directed towards clinicians who are responsible for fertility preservation in young boys/men undergoing cancer treatment.
Submission: Semen collection and cryopreservation for fertility preservation is an emotive and sometimes difficult process for young men recently diagnosed with cancer and about to undergo chemotherapy. Often marriage and children are their furthest thought, some may not even have become sexually active. This study identifies that projected dose is related to the future likelihood of adult sterility and therefore allows clinicians and clinic staff to gauge the extent of sample number for cryopreservation. The study also identifies that about 25% of clients are likely to be sterile as a result of treatment. The remaining appear to be either normal or oligospermic, both conditions can easily be treated with IVF or ICSI.
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