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Acrosome reaction is impaired in spermatozoa of obese men: a preliminary study
Sperm AR is impaired in obese men, showing reduced response to P and elevated Sp-AR, associated with altered circulating levels of E2 and sperm cholesterol content.
www.fertstert.org/article/S0015-0282(14)01889-5/abstract
100. Acrosome reaction is impaired in spermatozoa of obese men: a preliminary study [Forum/Discussion]
from: Administrator (office@fertaid.com), Australia on 18/09/2014 6:05:32 PM Profession:
Comment: Obsese male have impaired acrosome reaction (AR) profiles.
Submission: Testing for the acrosome reaction used to be a popular sperm function test but these days it is rarely discussed yet it remains the critical step for all IVF inseminations. This study reminds all that both in vivo and in vitro, this critical step needs to be completed after sperm zona binding. It appears that in obese males, more sperm undergo premature AR rendering a smaller population available to the oocyte and of these, fewer are likely to respond appropriately. It is a big step between in vitro testing to what happens naturally but it is not unreasonable to argue that in vitro IVF inseminations using sperm from obese males may need a review of concentrations added to the oocyte to compensate for spontaneous acrosome loss?? Good to see work still being done in this sometimes forgotten but critical step.
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