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A novel atypical sperm centriole is functional during human fertilization
Altogether, we show that the DC is compositionally and structurally remodeled into an atypical centriole, which functions as the zygote’s second centriole. These findings now provide novel avenues for diagnostics and therapeutic strategies for male infertility, and insights into early embryo developmental defects.
Relationship between blastocoel cell-free DNA and day-5 blastocyst morphology
This study provides further evidence that cfDNA is present in blastocoel fluid, can be quantified, and positively correlates with embryonic morphology. There is also evidence that at least a portion of the cfDNA present is from intracellular contents of embryonic cells that underwent apoptosis.
- View Link - Keywords: Blastocyst/Cell free DNA/blastocoel/
Human in vitro fertilization (IVF) has been around for 40 years and yet we still do not fully understand how to ensure the generation of healthy embryos and to prevent unwanted genetic or epigenetic changes that may arise during in vitro culture. Once the embryo is transferred to the uterus to continue gestation, early implantation and the initial phases of embryogenesis and placenta formation are hidden from easy access for research.
Infertility treatments during pregnancy and the risk of autism Spectrum disorder in the offspring
Results showed that IVF treatment compared with spontaneous conception was not statistically significantly associated with the risk of ASD. Only progesterone hormone treatment was associated with a statistically significant (p :< :.05) increased risk of ASD (RR := :1.51, 95% CI 1.22, 1.86) compared to the group with no progesterone treatment. In conclusion, progesterone exposure during the critical period of fetal life elevat
- View Link - Keywords:Autism Spectrum disorders/Infertility/Hormone/Epidemiology/